These data indicate a strong association of the SPEM lineage with both chronic H. Importantly, 59% of resections showed SP immunoreactivity within dysplastic cells. In a review of archival samples from 22 resected gastric adenocarcinomas, we found the SPEM lineage in 91% of cases, typically located in mucosa adjacent to the carcinoma or areas of dysplasia. The SPEM lineage was present in 68% of fundic biopsies from patients with fundic Helicobacter pylori-associated gastritis, but was absent in biopsies of fundic mucosa from patients without H. Given the epidemiological association of Helicobacter species infection with gastric cancer, we hypothesized that this SP-expressing metaplastic (SPEM) lineage may represent a precursor to or appear commensurate with gastric adenocarcinoma. This metaplastic lineage expresses the trefoil peptide spasmolytic polypeptide (SP). Wang et al (1998) have reported that an aberrant metaplastic cell lineage with morphological characteristics similar to Brunner's glands of the duodenum develops in the fundic mucosa of mice infected with Helicobacter felis. Although a subtype of intestinal metaplasia has been associated with gastric adenocarcinoma, the link between this lineage and the evolution of gastric adenocarcinoma has remained unclear. N2 - Metaplastic cell lineages arising in response to chronic injury are precursors for the evolution of dysplasia and adenocarcinoma. T1 - Identification of a metaplastic cell lineage associated with human gastric adenocarcinomaĬopyright 2007 Elsevier B.V., All rights reserved. pylori infection and gastric adenocarcinoma.',

pylori infection and gastric adenocarcinoma.Ībstract = 'Metaplastic cell lineages arising in response to chronic injury are precursors for the evolution of dysplasia and adenocarcinoma.

Metaplastic cell lineages arising in response to chronic injury are precursors for the evolution of dysplasia and adenocarcinoma.

Lineage w na